Khethani Mathikhi recently graduated with a Master of Science in Medicine degree, with a focus on Physiology, at Wits University. His primary area of research interest revolves around understanding the neurophysiological mechanisms related to substance use disorders. His ongoing research is centred on unravelling the acute behavioural and molecular impacts of the heroin-based nyaope street cocktail drug using an in vivo model. During his academic journey at the University of Limpopo, Mr. Mathikhi conducted research that delved into the epidemiology of substance abuse.

In addition to his academic pursuits, he has actively engaged in student leadership roles, as well as recently serving as both a Health Science Faculty postgraduate representative, School of Physiology postgraduate representative Academic Officer and legal representative for the Wits Postgraduate Association. Khethani currently is the Chairperson of the Young African Association of Physiological Sciences (YAAPS).

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Khethani has also represented South Africa at various international conferences, including prominent events such as the World Youth Summit, UMOJA African Student Leader Conference, Activate Leadership Change Driver, Model United Nations in Bali, and the One Young World International Conference, among others. Beyond his academic and leadership commitments, Khethani is an ardent reader, with a keen interest in biographies of African political leaders, historical memoirs, economics, and art. During his leisure time, he enjoys crafting essays based on his experiences growing up in villages. He is also a contributing writer for The South African online newspaper and frequents art exhibitions. Furthermore, Khethani is a sports enthusiast who actively coaches both the Wits Junction FC and Hurricanes FC.